personalize your breast cancer Treatment

Breast cancer

Similar to people, no two breast cancers are the same.  Myriad Oncology develops tests designed to empower you and your healthcare provider to make informed treatment decisions that are unique to your breast cancer.  

Your Cancer, Your Journey

Myriad is able to provide industry leading results that are specific to your breast cancer by investigating changes in your DNA. Armed with this information, you and your healthcare provider no longer have to use a one size fits all approach. You can start creating a treatment plan that is personalized to you.  

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Take the Breast Cancer Quiz to find out if any of the below solutions could be right for you

Myriad Oncology's Tests for Breast Cancer and What Answers They Provide:

Hereditary cancer testing

myRisk genetic testing
Myriad myRisk® is a gene panel that helps identify your options for treatment, your risk of additional cancers, and if any close family members may be at an elevated risk of developing cancer.

BREAST CANCER TUMOR TESTING – TO GUIDE TREATMENT AND RISK MANAGEMENT DECISIONS

EndoPredict® tailors your breast cancer treatment decisions based on personalized results specific to your cancer.

BrCA Testing – To help determine which patients may be appropriate for parp targeted therapy

BRACAnalysis CDx cancer testing
BRACAnalysis CDx® informs you if you’re eligible for advanced cancer treatments such as targeted therapies or clinical trials.

Breast Cancer prediction tool

riskScore breast cancer screening
For some women who have not been diagnosed with breast cancer, riskScore® predicts their 5-year and remaining lifetime risk of developing breast cancer.*

Hereditary cancer risk associated with breast cancer

Knowing whether your cancer was caused by a genetic mutation will help guide treatment decisions, determine your risk of developing additional cancers (like a second breast cancer or ovarian cancer), and identify your close family members’ risks of having the same mutation. Inherited mutations account for up to 14% of all breast cancers.1 By knowing your genetic risk factors, your doctor can better diagnose and treat your breast cancer.

If your cancer was caused by a genetic mutation, your children and siblings have a 50% chance of being diagnosed with that same mutation. Genetic testing for breast cancer helps identify multiple genetic mutations that are related to breast cancer, such as BRCA1 and BRCA2, and people with mutations in these genes have up to an 87% risk of developing breast cancer by 70.2 These individuals are also at a much higher risk of developing other cancers, like ovarian and pancreatic, than the general public.

To see if genetic testing will benefit you and your family, take The Hereditary Cancer Quiz.

What is Breast Cancer?3

Breast cancer occurs when abnormal cells within the breast start growing out of control. Occurring mostly in women, breast cancer may form a tumor that can be felt as a lump or seen on an x-ray. In their lifetime, 1 in 8 women in the US will be diagnosed. Although uncommon, breast cancer can also affect men.

When detected early, cancer located only in the breast has a 5-year survival rate of 99%. A majority of breast cancer is diagnosed at this stage. For invasive breast cancer (cancer that has spread), the average 5-year survival rate is 90%.

Risk factors for breast cancer may increase as you age. You can reduce some risk by staying active, maintaining a healthy weight, and avoiding alcohol. For genetic breast cancer, it is important to be screened for hereditary risks.

Breast Cancer Signs and Symptoms3

People may have different breast cancer symptoms or no symptoms at all. Breasts may change as people age, have children, or take different medications. If you want to know more about how to check for breast cancer, there are common symptoms to look for.

Common warning signs of breast cancer:

  • A lump in the breast or underarm
  • Irritation or dimpling of the skin on the breast
  • Parts of the breast thickening or swelling
  • Changes in the size or the shape of the breast
  • Redness or flaky skin in the nipple area or the breast
  • Pulling in of the nipple or pain in the nipple area
  • Nipple discharge other than breast milk, including blood

Not all lumps that form within the breast are cancerous. Non-cancerous tumors are called benign, while cancerous tumors are called malignant. Benign tumors are not life-threatening but may increase cancer risk

Breast Cancer Screening:3

Breast cancer screenings often begin based on a person’s age and family history. This information helps doctors decide which screening may be best. The most common breast cancer screenings are:

  1. Mammography

Using an x-ray, doctors are able to see into the breast. This detailed view helps doctors identify abnormal cell growth. It is less effective for dense breast tissue, which is common in younger women.

  1. Magnetic Resonance Imaging (MRI)

Uses radio waves and strong magnets to make detailed pictures of the inside of the breasts.

Breast Cancer Staging:3

After someone is diagnosed with breast cancer, doctors will try to figure out if it has spread, and if so, how far. This process is called staging. The stage of a cancer describes how much cancer is in the body. It helps determine how serious the cancer is and how best to treat it. Doctors also use a cancer’s stage when talking about survival statistics.

The staging system most often used for breast cancer is the American Joint Committee on Cancer (AJCC) TNM system.

7 key pieces of information are usually used:

  • The extent (size) of the tumor (T): How large is the cancer?  Has it grown into nearby areas?
  • The spread to nearby lymph nodes (N): Has the cancer spread to nearby lymph nodes? If so, how many?
  • The spread (metastasis) to distant sites (M): Has the cancer spread to distant organs such as the lungs or liver?
  • Estrogen Receptor (ER) status: Does the cancer have the protein called an estrogen receptor?
  • Progesterone Receptor (PR) status: Does the cancer have the protein called a progesterone receptor?
  • HER2 status: Does the cancer make too much of a protein called HER2?
  • Grade of the cancer (G): How much do the cancer cells look like normal cells?

Breast cancer is best treated the earlier it is detected. Your doctor will help you identify what stage your cancer is, and how best to treat it.

 

Breast Cancer Treatment Options3

There are different breast cancer treatment options your healthcare provider will recommend that depend on the stage of your cancer. Those options may include surgery, chemotherapy, and radiation. Your doctor may recommend using one or more of these treatments:

Surgery

A mastectomy is a surgery that removes the whole breast. A lumpectomy removes just the tumor and the tissue around it.

Radiation Therapy

High-energy waves are administered into the breast to control and kill cancer cells.

Chemotherapy

One or more anti-cancer drugs are used to stop the growth and kill cancer cells.

Often used together, these breast cancer treatments can help remove any traces of the cancer left behind.

With genetic testing you could find that you are eligible for other targeted treatments or clinical trials. Talk with your doctor about genetic testing and all the risks, side effects, and benefits of each treatment.

What is Breast Cancer?3

Breast cancer occurs when abnormal cells within the breast start growing out of control. Occurring mostly in women, breast cancer may form a tumor that can be felt as a lump or seen on an x-ray. In their lifetime, 1 in 8 women in the US will be diagnosed. Although uncommon, breast cancer can also affect men.

When detected early, cancer located only in the breast has a 5-year survival rate of 99%. A majority of breast cancer is diagnosed at this stage. For invasive breast cancer (cancer that has spread), the average 5-year survival rate is 90%.

Risk factors for breast cancer may increase as you age. You can reduce some risk by staying active, maintaining a healthy weight, and avoiding alcohol. For genetic breast cancer, it is important to be screened for hereditary risks.

Breast Cancer Signs and Symptoms3

People may have different breast cancer symptoms or no symptoms at all. Breasts may change as people age, have children, or take different medications. If you want to know more about how to check for breast cancer, there are common symptoms to look for.

Common warning signs of breast cancer:

  • A lump in the breast or underarm
  • Irritation or dimpling of the skin on the breast
  • Parts of the breast thickening or swelling
  • Changes in the size or the shape of the breast
  • Redness or flaky skin in the nipple area or the breast
  • Pulling in of the nipple or pain in the nipple area
  • Nipple discharge other than breast milk, including blood

Not all lumps that form within the breast are cancerous. Non-cancerous tumors are called benign, while cancerous tumors are called malignant. Benign tumors are not life-threatening but may increase cancer risk

Breast Cancer Screening:3

Breast cancer screenings often begin based on a person’s age and family history. This information helps doctors decide which screening may be best. The most common breast cancer screenings are:

  1. Mammography

Using an x-ray, doctors are able to see into the breast. This detailed view helps doctors identify abnormal cell growth. It is less effective for dense breast tissue, which is common in younger women.

  1. Magnetic Resonance Imaging (MRI)

Uses radio waves and strong magnets to make detailed pictures of the inside of the breasts.

Breast Cancer Staging:3

After someone is diagnosed with breast cancer, doctors will try to figure out if it has spread, and if so, how far. This process is called staging. The stage of a cancer describes how much cancer is in the body. It helps determine how serious the cancer is and how best to treat it. Doctors also use a cancer's stage when talking about survival statistics.

The staging system most often used for breast cancer is the American Joint Committee on Cancer (AJCC) TNM system.

7 key pieces of information are usually used:

  • The extent (size) of the tumor (T): How large is the cancer?  Has it grown into nearby areas?
  • The spread to nearby lymph nodes (N): Has the cancer spread to nearby lymph nodes? If so, how many?
  • The spread (metastasis) to distant sites (M): Has the cancer spread to distant organs such as the lungs or liver?
  • Estrogen Receptor (ER) status: Does the cancer have the protein called an estrogen receptor?
  • Progesterone Receptor (PR) status: Does the cancer have the protein called a progesterone receptor?
  • HER2 status: Does the cancer make too much of a protein called HER2?
  • Grade of the cancer (G): How much do the cancer cells look like normal cells?

Breast cancer is best treated the earlier it is detected. Your doctor will help you identify what stage your cancer is, and how best to treat it.

Breast Cancer Treatment Options3

There are different breast cancer treatment options your healthcare provider will recommend that depend on the stage of your cancer. Those options may include surgery, chemotherapy, and radiation. Your doctor may recommend using one or more of these treatments:

Surgery

A mastectomy is a surgery that removes the whole breast. A lumpectomy removes just the tumor and the tissue around it.

Radiation Therapy

High-energy waves are administered into the breast to control and kill cancer cells.

Chemotherapy

One or more anti-cancer drugs are used to stop the growth and kill cancer cells.

Often used together, these breast cancer treatments can help remove any traces of the cancer left behind.

With genetic testing you could find that you are eligible for other targeted treatments or clinical trials. Talk with your doctor about genetic testing and all the risks, side effects, and benefits of each treatment.

References

*riskScore is calculated for women of solely European ancestry under the age of 85 without a personal history of breast cancer, LCIS, hyperplasia, atypical hyperplasia, or a breast biopsy of unknown results. riskScore is not calculated if a woman or a blood relative is known to carry a mutation in a breast cancer gene. 

  1. Foulkes WD. Inherited susceptibility to common cancers. N Engl J Med 2008:359:2143-2153
  2. Ford D, et al. Risks of cancer in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Lancet. 1994; 343(8899):692-5.
  3. American Cancer Society. Cancer Facts and Figures 2020. Atlanta, Ga: American Cancer Society; 2020.
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